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Risk Factors for SARS among Persons without Known Contact with SARS Patients, Beijing, China

机译:中国北京,未与SARS患者接触的人群中SARS的危险因素

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摘要

Most cases of severe acute respiratory syndrome (SARS) have occurred in close contacts of SARS patients. However, in Beijing, a large proportion of SARS cases occurred in persons without such contact. We conducted a case-control study in Beijing that compared exposures of 94 unlinked, probable SARS patients with those of 281 community-based controls matched for age group and sex. Case-patients were more likely than controls to have chronic medical conditions or to have visited fever clinics (clinics at which possible SARS patients were separated from other patients), eaten outside the home, or taken taxis frequently. The use of masks was strongly protective. Among 31 case-patients for whom convalescent-phase (>21 days) sera were available, 26% had immunoglobulin G to SARS-associated coronavirus. Our finding that clinical SARS was associated with visits to fever clinics supports Beijing’s strategy of closing clinics with poor infection-control measures. Our finding that mask use lowered the risk for disease supports the community’s use of this strategy.
机译:严重急性呼吸系统综合症(SARS)的大多数病例都发生在SARS患者的密切接触中。但是,在北京,没有这种接触的人中有很大一部分发生了SARS病例。我们在北京进行了一项病例对照研究,比较了94例无关联,可能的SARS患者与281个基于年龄组和性别匹配的社区对照人群的暴露情况。与对照相比,案例患者更有可能患有慢性病或去发烧诊所(可能将SARS患者与其他患者分开的诊所),在家里吃饭或经常乘坐出租车。口罩的使用具有很强的保护作用。在31例恢复期血清(> 21天)的患者中,有26%的患者具有针对SARS相关冠状病毒的免疫球蛋白G。我们发现临床SARS与发烧诊所就诊有关,这支持了北京关闭感染控制措施不佳的诊所的策略。我们发现使用口罩可降低疾病风险,这支持了社区对这种策略的使用。

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